The Science of Things

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Feature: Seeking ways to crack cocaine addiction
The Lancet [Volume 352, Number 9136] 17 October 1998
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Science and Medicine: Data accrue on "visionary" agent to interrupt addiction
The Lancet [Volume 354, Number 9193] 27 November 1999
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Papers
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Ibogaine:
Complex Pharmacokinetics, DEBORAH
C. MASH, CRAIG A. KOVERA, JOHN PABLO, |
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Abstracts
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IBOGAINE IS EFFECTIVE IN BLOCKING OPIATE WITHDRAWAL SYMPTOMS: ROLE OF THE METABOLITE NORIBOGAINE
J. Pablo, C.A. Kovera and D.C. Mash. Neurology Dept., Univ. of Miami School of Med., Miami, FL.
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Modified ibogaine fragments: synthesis and preliminary
pharmacological characterization of 3-ethyl-5-phenyl-1,2,3,4,5, 6-hexahydroazepino[4,5-b]benzothiophenes.
Efange SM, Mash DC, Khare AB, Ouyang Q
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Cytochrome P4502D6 catalyzes the O-demethylation
of the psychoactive alkaloid ibogaine to 12-hydroxyibogamine.
Obach RS, Pablo J, Mash DC
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Medication development of ibogaine as a pharmacotherapy
for drug dependence.
Mash DC, Kovera CA, Buck BE, Norenberg MD, Shapshak P, Hearn WL, Sanchez-Ramos
J
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Noribogaine stimulates naloxone-sensitive [35S]GTPgammaS
binding.
Pablo JP, Mash DC
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Pharmacological screen for activities of 12-hydroxyibogamine:
a primary metabolite of the indole alkaloid ibogaine.
Staley JK, Ouyang Q, Pablo J, Hearn WL, Flynn DD, Rothman RB, Rice KC,
Mash DC
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Identification and quantitation of ibogaine
and an o-demethylated metabolite in brain and biological fluids using gas
chromatography-mass spectrometry.
Hearn WL, Pablo J, Hime GW, Mash DC
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Properties of ibogaine and its principal metabolite
(12-hydroxyibogamine) at the MK-801 binding site of the NMDA receptor complex.
Mash DC, Staley JK, Pablo JP, Holohean AM, Hackman JC, Davidoff RA
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Identification of a primary metabolite of ibogaine that targets serotonin transporters and elevates serotonin.
Mash DC, Staley JK, Baumann MH, Rothman RB, Hearn WL
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Noribogaine generalization to the ibogaine stimulus:
correlation with noribogaine concentration in rat brain.
Zubaran C, Shoaib M, Stolerman IP, Pablo J, Mash DC
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