The Science of Things

Feature: Seeking ways to crack cocaine addiction

The Lancet [Volume 352, Number 9136] 17 October 1998

Science and Medicine: Data accrue on "visionary" agent to interrupt addiction

The Lancet [Volume 354, Number 9193] 27 November 1999  

 

Papers

Ibogaine: Complex Pharmacokinetics,
Concerns for Safety, and Preliminary Efficacy Measures

DEBORAH C. MASH, CRAIG A. KOVERA, JOHN PABLO,
RACHEL F. TYNDALE, FRANK D. ERVIN, IZBEN C. WILLIAMS,
EDWARD G. SINGLETON AND MANNY MAYOR

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Abstracts

IBOGAINE IS EFFECTIVE IN BLOCKING OPIATE WITHDRAWAL SYMPTOMS: ROLE OF THE METABOLITE NORIBOGAINE

 

J. Pablo, C.A. Kovera and D.C. Mash.  Neurology Dept., Univ. of Miami School of Med., Miami, FL.

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Modified ibogaine fragments: synthesis and preliminary pharmacological characterization of 3-ethyl-5-phenyl-1,2,3,4,5, 6-hexahydroazepino[4,5-b]benzothiophenes.

Efange SM, Mash DC, Khare AB, Ouyang Q

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Cytochrome P4502D6 catalyzes the O-demethylation of the psychoactive alkaloid ibogaine to 12-hydroxyibogamine.

Obach RS, Pablo J, Mash DC

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Medication development of ibogaine as a pharmacotherapy for drug dependence.

Mash DC, Kovera CA, Buck BE, Norenberg MD, Shapshak P, Hearn WL, Sanchez-Ramos J

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Noribogaine stimulates naloxone-sensitive [35S]GTPgammaS binding.

Pablo JP, Mash DC

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Pharmacological screen for activities of 12-hydroxyibogamine: a primary metabolite of the indole alkaloid ibogaine.

Staley JK, Ouyang Q, Pablo J, Hearn WL, Flynn DD, Rothman RB, Rice KC, Mash DC

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Identification and quantitation of ibogaine and an o-demethylated metabolite in brain and biological fluids using gas chromatography-mass spectrometry.

Hearn WL, Pablo J, Hime GW, Mash DC

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Properties of ibogaine and its principal metabolite (12-hydroxyibogamine) at the MK-801 binding site of the NMDA receptor complex.

Mash DC, Staley JK, Pablo JP, Holohean AM, Hackman JC, Davidoff RA

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Identification of a primary metabolite of ibogaine that targets serotonin transporters and elevates serotonin.

Mash DC, Staley JK, Baumann MH, Rothman RB, Hearn WL

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Noribogaine generalization to the ibogaine stimulus: correlation with noribogaine concentration in rat brain.

Zubaran C, Shoaib M, Stolerman IP, Pablo J, Mash DC

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