Deborah C. Mash, Ph.D. 



          Dr. Deborah Mash is a Professor of Neurology and Molecular and Cellular Pharmacology at the University of Miami School of Medicine. She is the Director of the University of Miami Brain Endowment Bank. The Brain Bank program has received national recognition for educating the public about the importance of brain donation during the Decade of the Brain (1990-2000).


          Dr. Mash received her BA degree from Florida State University, Tallahassee, FL, and her PhD degree in pharmacology (neuropharmacology) from the University of Miami, Miami, FL. She completed a postdoctoral fellowship in neurology (and neuroanatomy) at the Beth Israel Hospital, Harvard Medical School, Boston, MA. After completing her fellowship at Harvard Medical School, she joined the Department of Neurology at the University of Miami School of Medicine in 1986. She is recognized nationally and internationally as a neuroscientist and neuropharmacologist, who has held peer-reviewed basic research grants continuously for the past twelve years. Her studies on aging, neurodegenerative and neuropsychiatric disorders, and drug and alcohol research has been reported in over 200 articles, monographs and presentations at national and international meetings.  Her research work as a young neuroscientist won her early recognition for studies in Alzheimer's disease and muscarinic receptors. This seminal work led to a new direction for drug development in Alzheimer's disease.


          More recently, her work on the effects of cocaine on the brain and the discovery of the novel cocaine and alcohol metabolite -- cocaethylene -- brought national and international recognition to the University of Miami School of Medicine. The discovery of cocaethylene -- termed the Miami Vice Metabolite in Science Magazine, helped to explain the epidemic of deaths in Dade County, FL along with the rise in popularity of combined cocaine and alcohol use in the late 1980s. She is currently studying an African rainforest alkaloid -- ibogaine -- as a potential anti-cocaine medication. In addition, studies underway in her laboratory indicate that the current epidemic of cocaine abuse may lead to a new wave of Parkinson's disease in aging cocaine addicts.


          Dr. Mash continues to work with a team of neuroscientists, pharmacologists, toxicologists and clinical scientists to bring basic discoveries from her laboratory bench to the patient's bedside. Her research emphasis targets major public health concerns for the millennium: Diseases of the aging brain, drug and alcohol abuse and dependence.


University of Miami

School of Medicine

Department of Neurology (D4-5)

P.O. Box 016960

Miami, Florida 33101

(305) 243-6732